BASE EDITING · Changing a Base Without Cutting — Oversized Drop-Should

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TEE-MED-PR-BAS-01-M-BK T-Shirt

Piece

BASE EDITING · Changing a Base Without Cutting Oversized Drop-Shoulder T-Shirt

$ 2,345.00

Description

Described in 2016, base editing turns one letter of DNA into another without cutting the double strand, which is where CRISPR gets it wrong. Printed here is that chemical conversion on the intact chain.

A Author

Edición de bases

B Subject

Genetics

C Aesthetic

Diagram · Typographic

Exploration

CRISPR cuts both strands of DNA and lets the cell repair. Repair is careless by nature, and that is why it serves to spoil a gene and serves badly to fix one.

Base editing does not cut. It carries a deactivated enzyme that opens only one strand and, bound to it, a chemical enzyme that converts one letter into another directly on the intact chain.

A cytosine becomes a thymine, or an adenine a guanine. Those are the two conversions available, and between them they cover a good part of the known point mutations.

In 2022 an adolescent with resistant leukaemia received donor lymphocytes with six edits of this kind and went into remission. It was the last resort available.

The risk is not the cut but the chemical precision: the enzyme can edit neighbouring letters or RNA that happened to be passing, and that leaves no visible scar.

Details